Avra Lab is a leading Active Pharmaceutical Ingredients (API) manufacturer founded by a scientist renowned as one of the most distinguished ones in India. We focus on over 7 therapeutic areas and manufacture advanced API formulations with a commitment to quality. Our products cater to pharma companies all over the world with a record of over 25 years of excellence.
We are the Active Pharmaceutical Ingredients (API) suppliers of Lenalidomide, Misoprostol, Ticagrelor, Carfilzomib, Palbociclib, Eltrombopag Olamine, Macitentan, Pimavanserin and more.
API Products List
| Therapeutic Area | Products | Status |
| Anti-Cancer | Irinotecan Hydrochloride | USDMF No. 30516 / CEP (Pipeline)/ WHO GMP |
| Anti-Thrombotic | Ticagrelor | USDMF No. 033937 / WHO GMP |
| Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. The drug is produced by AstraZeneca. Avra provides complete GMP manufacturing of Ticagrelor and has a USDMF filed with number 033937 | ||
| Anti-Cancer | Lenalidomide | Open part DMF/ WHO GMP |
| Lenalidomide is an Oncology drug sold under the trade name Revlimid and is a medication used to treat multiple myeloma and myelodysplastic syndromes among others. Lenalidomide was approved for medical use in the United States in 2005 and was launched by Celgene. It is on the World Health Organization’s List of Essential Medicines. Avra provides complete GMP manufacturing of Lenalidomide API for Form-A, Form-B and Form-I and has an Open Part DMF available. | ||
| Anti-Ulcer | Misoprostol 1% dispersion in HPMC | Tech Pack |
| Anti-Cancer | Pazopanib Hydrochloride | COA and samples (ODMF-Pipeline) |
| Anti-Cancer | Carfilzomib | COA and samples |
| Anti-Cancer | Methotrexate | COA and samples (ODMF-Pipeline) |
| Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma. Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn’s disease. Avra provides complete GMP manufacturing of Methotrexate. | ||
| Anti-Cancer | Topotecan Hydrochloride | COA |
| Anti-Cancer | Palbociclib | R&D |
| Hematology | Eltrombopag Olamine | COA and samples (ODMF-Pipeline) |
| Eltrombopag is a medication that has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet counts). It was discovered as a result of research collaboration between GlaxoSmithKline and Ligand Pharmaceuticals. It is being manufactured and marketed by Novartis under the trade name Promacta in the US and is marketed as Revolade in the EU. Avra provides complete GMP manufacturing of Eltrombopag Olamine API. | ||
| PAH | Macitentan | R&D |
| Psoriatic Arthritis | Apremilast | R&D |
| Apremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. It may also be useful for other immune system related inflammatory diseases. Avra provides complete GMP manufacturing of Apremilast. | ||
| Antipsychotic | Pimavanserin | R&D |
| Name | CAS No. |
| Irinotecan Intermediates | |
| 7-Ethyl-10-hydroxycamptothecin (SN-38) (USDMF No. 27429) | 86639-52-3 |
| SN-38 is an antineoplastic drug in the Oncology segment. It is the active metabolite of Irinotecan. Antibody-drug conjugates (ADCs) that exploit the active metabolite SN-38 have shown great promise in new cancer treatment technologies. Avra provides complete GMP manufacturing of fully synthetic SN-38 in a USFDA approved facility and has USDMF filed with number 27429 | |
| (S)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro-6-oxa-3a-aza-cyclopenta [b]naphthalene-1,4,7-trione | 110351-94-5 |
| S-Trione is an intermediate of SN-38, which is an antineoplastic drug in the Oncology segment and the active metabolite of Irinotecan. Avra provides complete GMP manufacturing of fully synthetic S-Trione. | |
| 2’-Amino-5’-hydroxypropiophenone | 35364-15-9 |
| Topotecan Intermediate | |
| 10-Hydroxycamptothecin (USDMF No. 26025) | 19685-09-07 |
| Pazopanib HCl Intermediate | |
| 2,4-Dichloropyrimidine | 3934-20-1 |
| 2,4-Dichloropyrimidine is used direclty as a human skin sensitizer. It is also used in the manufacturing of Pazopanib. Pazopanib, sold under the brand name Votrient, is an anti-cancer medication. It has been approved for renal cell carcinoma and soft tissue sarcoma by numerous regulatory administrations worldwide. Avra provides complete GMP manufacturing of 2,4-Dichloropyrimidine | |
| 5-Amino-2-methylbenzenesulfonamide | 6973-09-7 |
| Ticagrelor Intermediate | |
| 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d](1,3)dioxol-4-yl)oxy)ethanol, | 274693-26-4 |
| Carfilzomib Intermediates | |
| (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid | 868540-16-3 |
| (S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt | 247068-85-5 |
| Osimertinib Intermediates | |
| 4-Fluoro-2-methoxy-5-nitroaniline | 1075705-01-9 |
| N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine | 1421372-94-2 |
| Dapagliflozin and Ertugliflozin Intermediates | |
| (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone | 461432-22-4 |
| 5-Bromo-2-chloro-4′-ethoxydiphenylmethane | 461432-23-5 |
| Eltrombopag Olamine | |
| 3′-amino-2′-hydroxy-1,1′-biphenyl-3-carboxylic acid | 376592-93-7 |
| 2-Methoxy-3-nitrobiphenyl-3-carboxylic acid | 376591-94-5 |
| 2-bromo-6-nitrophenol | 13073-25-1 |
| Others | |
| Camptothecin | 7689-03-4 |
| Camptothecin is an anti-cancer drug compund isolated from the bark and stem of the tree, Camptotheca acuminata. Avra holds a patented process and is the world’s largest producer for fully-synthetic manufacturing of Camptothecin derivates including Irinotecan, SN-38, S-Trione, AHP and Topotecan intermediates | |
| 7-Ethylcamptothecin | 78287-27-1 |
| Olivetol | 500-66-3 |
| Methyl olivetolate | 58016-28-7 |
| 3-Oxocyclobutanecarboxylic acid | 23761-23-1 |
| 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline | 14446-24-3 |
| 2-Amino-5-bromobenzaldehyde | 29124-57-0 |
| 2,4-Dimethoxypyrimidine | 3551-55-1 |
| Quinoxaline-2-carboxaldehyde | 1593-08-4 |
| 2-Chloro-1,3,2-dioxaphospholane 2-oxide | 6609-64-9 |
| 3,4-benzyloxybenzaldehyde | 5447-02-9 |
| 2-Ethylmorpholine | 52769-10-5 |
| 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester | 286961-14-6 |
| trans-1-Propenylboronic acid pinacol ester | 83947-58-4 |
| Trimethylsulfoxonium chloride | 5034-06-0 |
| Tri-tert-butylphosphoniumtetrafluoroborate | 131274-22-1 |
| 2-phenylpyridine | 1008-89-5 |
| 3-Hydroxyazetidine hydrochloride | 18621-18-6 |
| 3-Bromopyridazine Hydrobromide | —- |